Abstract
A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Binding, Competitive
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Cannabinoid Receptor Agonists
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Cannabinoid Receptor Antagonists*
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Cerebellum / metabolism
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Guinea Pigs
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Ileum / drug effects
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Ileum / physiology
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In Vitro Techniques
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Male
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Mice
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Muscle, Smooth / physiology
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Radioligand Assay
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Rats
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / pharmacology
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Vas Deferens / drug effects
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Vas Deferens / physiology
Substances
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Cannabinoid Receptor Agonists
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Cannabinoid Receptor Antagonists
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Triazoles